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Vitamin A effective in wrinkle reduction

Article-Vitamin A effective in wrinkle reduction

Ann Arbor, Mich.—A University of Michigan Medical School study suggests that lotion containing vitamin A (retinol) may help reduce age-induced wrinkles and help boost production of skin-building compounds, reports HealthDay News.

The study, findings of which were published in the May issue of the Archives of Dermatology, involved 36 elderly people (average age, 87) on whom researchers applied 0.4 percent retinol lotion to the upper-arm and control lotion with no retinol to the other arm. The lotions were applied up to three times a week for 24 weeks.

The researchers graded the wrinkles, roughness and overall severity of skin aging before treatment and at two, four, eight, 16 and 24 weeks after starting treatment. Skin biopsies from both arms were taken at the beginning and end of the 24-week treatment period.

The study found that wrinkles, roughness and overall aging were significantly reduced where the retinol lotion had been applied, compared with the arms treated with the control lotion.

Post-treatment biopsies showed increased production of glycosaminoglycan and procollagen on arms that received the retinol lotion.

The study was funded by grants from the National Institutes of Health, the Babcock Endowment for Dermatologic Research, the Merck-American Federation for Aging Research and the Alpha Omega Alpha Student Research Fellowship.

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