Biomimetic Exosomes for Stability in Skincare

Exosomes are increasingly being used in aesthetics both in-office as topical treatment solutions to enhance the skin’s regenerative processes and in homecare products to continually expose the skin to a regenerative environment. As more manufacturers are developing their own lines of exosome products, the challenge becomes navigating the technological complexities to keep exosomes viable when mixed into complex emulsions.

Kevin A. Wilson

October 30, 2024

3 Min Read
The Aesthetic Guide logo in a gray background | The Aesthetic Guide

Exosomes are increasingly being used in aesthetics both in-office as topical treatment solutions to enhance the skin’s regenerative processes and in homecare products to continually expose the skin to a regenerative environment. As more manufacturers are developing their own lines of exosome products, the challenge becomes navigating the technological complexities to keep exosomes viable when mixed into complex emulsions.

AnteAGE® (Irvine, Calif.) resolves this issue with Biosomes™, a synthetic analog of human-derived exosomes. While AnteAGE MDX Exosome solution is their flagship exosome product, the company is advancing their exosome platform into homecare products after a decade of research. The Company created Biosomes to replicate the functions of stem cell-derived exosomes, with customizable stability for a variety of applications in both treatment solutions and daily skincare routines.

Launching in September 2024, AnteAGE Biosome Serum and AnteAGE Biosome Accelerator are daily topical skincare products that combine the regenerative functions of Biosomes with nano-engineering strategies to protect the nanoparticles from the oil and surfactant-rich environments found within skincare products.

According to dermatologist Lesley Clark-Loeser, MD, at Precision Skin Institute in Davie, Fla., once reconstituted, exosomes are stable for a short time, while synthetic exosomes offer an added layer of stability with customized efficacy. “Exosomes enhance cell-to-cell communication, but human- or plant-derived exosomes may not be ideal for our intended purpose,” she explained. “Engineered Biosomes are precise in terms of what that profile looks like, so the final product is targeted and controlled, offering a precise, reproducible outcome. The brightening effects of Biosomes treat pigmentation issues and we plan to transition from microneedling with platelet-rich-plasma (PRP) to Biosomes to target pathways for hair regrowth.”

“Biomimetic exosomes are registered with the FDA (under the new Modernization of Cosmetic Regulations Act of 2022) and have shown equivalent efficacy to human-derived Exosomes," reported facial plastic surgeon Yael Halaas, MD, (New York City, N.Y.). "Synthetic exosomes can be specifically engineered to address specific skin concerns, making them a versatile tool in aesthetic and regenerative medicine. Biosomes can target particular skin concerns using natural signaling pathways favored by youthful skin without containing any negative/inflammatory bio signals, offering a customized approach.”

Dr. Halaas added that AnteAGE Biosomes can be integrated into treatments such as microneedling and laser resurfacing and are particularly useful in procedures that involve skin rejuvenation and repair, as they help to accelerate healing and enhance overall results. “Integrating exosomes into treatments allows practitioners to offer innovative, science-based solutions that set their practices apart. This can attract more patients seeking advanced skincare options for improved skin texture and reduced signs of aging with highly effective and satisfying outcomes,” she reported.

"Natural exosomes are wonderful; however, they have limited potential for modification," according to Marjon Vatanchi, MD, a double-board certified dermatologist at Irvine Dermatology (Irvine, Calif.). "Biomimetic exosomes meet various diagnostic needs, and their creation can be controlled ensuring consistency and desired results.”

Exposing the skin to Biosomes with daily skincare products can result in greater benefits when also combined with MDX exosome in-office treatments. “Patients like state-of-the-art products that assist with anti-aging,” Dr. Vatanchi noted. “Exosomes are the best modification to topical transmission of products on a molecular level. Their incorporation has elevated the cosmetic portion of my practice so I can offer a high-level product at a reasonable price.”

Subscribe to receive the latest in aesthetic medicine.
Get breaking developments, expert product comparisons, clinical roundtables, and practice strategies—all for free.