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DefenAge complements any aesthetic practice

Article-DefenAge complements any aesthetic practice


Backed by rigorous science, DefenAge® from Progenitor Biologics, LLC (Carlsbad, Calif.), not only provides patients with reliable, age-defying skincare, but gives physicians a reliable and profitable tool in their armamentarium. Thorough study has defined the product’s mechanism of action, safety and efficacy,1 so practitioners can confidently recommend DefenAge and the outcomes regularly seen with daily use.

DefenAge is also extremely versatile, and ideal for use in conjunction with other common therapeutic vectors.

Like many of her peers, dermatologist Leslie Baumann, M.D., founder and director of Baumann Cosmetic Dermatology in Miami, Fla., who is also an author, researcher and CEO of Skin Type Solutions Franchise Systems, was drawn to the scientific evidence supporting DefenAge.

“I lecture a lot and physicians in the audience kept asking about DefenAge, so I called the company and pummeled them with questions. They sent me copies of their research articles, which I studied, and then I used the product. I was a fan within three or four weeks, when patients returning for follow-up were visibly improving in such a short time with a topical. I incorporated DefenAge into my Skin Type Solutions software to automatically generate skincare regimens, and I have seen amazing results in more than 100 patients.”

The three-product regimen known as DefenAge’s Clinical Power Trio includes 8-in-1 BioSerum and 24/7 Barrier Balance Cream for twice-daily use, and 2-Minute Reveal Masque for use once or twice a week. Some physicians have tried applying individual products for specific applications.

Key actors in the DefenAge regimen are Age-Repair Defensins, which message existing dormant LGR6+ master stem cells – the antecedent for all skin cell lines, which are vital to the regenerative wound healing cascade. DefenAge is also formulated with compounds such as antioxidants known to be beneficial to skin, while avoiding commonly-used constituents suspected of being harmful.

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Before introducing DefenAge into her proprietary customized skincare paradigm, Dr. Baumann did some independent study to see how well the unique topicals would fit into her system. “The Skin Type Solutions Skin Typing System divides patients into 16 unique skin types,” she explained. “I found that DefenAge 8-in-1 BioSerum woks well in 12 of 16 Baumann skin types. It helps patients see an improvement in their skin sooner, which positively affects compliance with the rest of their regimen.” Dr. Baumann uses the 8-in-1 BioSerum in combination with retinoids and glycolic acid in wrinkle-prone skin types, and in combination with a tyrosinase inhibitor in pigmented skin types.

Dr. Baumann added that she most commonly recommends DefenAge to her photo-aging and melasma patients. “I am convinced it speeds clearing of melasma. I have more than 120 physicians now using my software and many of them also report good results with DefenAge.” To learn more about Dr Baumann’s skin type solutions software visit

1. Taub A, Bucay V, Keller G, Williams J, Mehregan D. Multi-center, double-blind, vehicle-controlled clinical trial of an alpha and beta defensin-containing anti-aging skin care regimen with clinical, histopathologic, immunohistochemical,  photographic, and ultrasound evaluation. J Drugs Dermatol 2018;17(4):426-441.